解剖学和形态学
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听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
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综合和补充性医学
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医学,全科和内科
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病理学
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药理学和药剂学
生理学
基本医疗保健
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泌尿学和肾脏学
病毒学
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健康政策和服务
心理学,临床
abstract::Prostaglandin E(2) (PGE(2)) is a major mediator in the pathophysiology, and pathogenesis of gynecological diseases associated with abnormal endometrial disease with proliferation and inflammation, such as endometriosis. In this study, we investigated the effect of dienogest, a selective progesterone receptor agonist, ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.08.010
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:The cut-off value for salivary cortisol measurement for the diagnosis of Cushing's syndrome (CS) may depend both on the severity of the disease and the composition of control group. Therefore, we examined the utility of midnight salivary cortisol measurements in patients who were evaluated for signs and sympt...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.08.007
更新日期:2011-01-01 00:00:00
abstract::A series of novel methyl spongoate (1) analogs has been synthesized and evaluated for their in vitro cytotoxic properties. It was found that the nature of the C-20 side chain had significant effects on their bioactivities and some analogs showed higher cytotoxicity than 1 against A549, HCT-116, HepG2, SW-1990, MCF-7 a...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.08.002
更新日期:2010-12-12 00:00:00
abstract::Variations in sex steroids bioavailability were linked to the gender difference in the growth of thyroid glands of neonatal rats. In the present study we tested androgen receptor (AR) and estrogen receptor (ER) concentrations by ligand binding assay, and expression of their genes by RT-PCR and Western blot in the thyr...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.06.009
更新日期:2010-12-12 00:00:00
abstract::It has been previously demonstrated that 1,25 dihydroxyvitamin D(3) (1,25-D(3)) exerts inhibitory effects in breast cancer cells. The aim of this study was to determine whether mitogen-activated protein kinase (MAPK) pathways are associated with 1,25-D(3)-induced cell death in breast cancer. We used three breast cell ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.07.007
更新日期:2010-12-12 00:00:00
abstract::20S-hydroxyvitamin D3 (20S-(OH)D3), an in vitro product of vitamin D3 metabolism by the cytochrome P450scc, was recently isolated, identified and shown to possess antiproliferative activity without inducing hypercalcemia. The enzymatic production of 20S-(OH)D3 is tedious, expensive, and cannot meet the requirements fo...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.05.021
更新日期:2010-12-01 00:00:00
abstract::Carbon-11-labeled casimiroin analogues were first designed and synthesized as new potential PET agents for imaging of quinone reductase (QR) 2 and aromatase expression in breast cancer. [(11)C]casimiroin (6-[(11)C]methoxy-9-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one, [(11)C]11) and its carbon-11-labeled analogues 5,...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.06.004
更新日期:2010-12-01 00:00:00
abstract::Androstane brassinosteroid analogues with alpha-azido acid ester groups in position 17beta were synthesized from 2alpha,3alpha,17beta-trihydroxy-5alpha-androstan-6-one after the protection of the 2alpha,3alpha-diols upon treatment with the corresponding alpha-azido acid and the subsequent deprotection of the diol grou...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.06.012
更新日期:2010-12-01 00:00:00
abstract::This article has been withdrawn at the request of the Publisher and the Editor-in-Chiefs. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.11.002
更新日期:2010-11-12 00:00:00
abstract::Biologic sex and sex steroids are important factors in clinical and experimental stroke. This review evaluates key evidence that biological sex strongly alters mechanisms and outcomes from cerebral ischemia. The role of androgens in male stroke is understudied and important to pursue given that male sex is a well know...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2009.10.014
更新日期:2010-11-01 00:00:00
abstract::The Na-K-2Cl cotransporter (NKCC2) regulates sodium transport along the thick ascending limb of Henle's loop and is important in control of sodium balance, renal concentrating ability and renin release. To determine if there are sex differences in NKCC2 abundance and/or distribution, and to evaluate the contribution o...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.05.014
更新日期:2010-11-01 00:00:00
abstract::Gene therapy based on gene delivery is a promising strategy for the treatment of various human diseases such as cancer. Cationic lipids represent one of the important synthetic gene delivery systems. There is a great interest in imaging of gene therapy using the biomedical imaging technique positron emission tomograph...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.04.009
更新日期:2010-10-01 00:00:00
abstract::Recent studies by several research groups have shown that G protein estrogen receptor-1 (GPER) formerly known as GPR30, mediates 17beta-estradiol (E2) activation of signal transduction pathways in a variety of human cancer cells and displays E2 binding typical of a membrane estrogen receptor. However, the importance o...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2009.11.005
更新日期:2010-08-01 00:00:00
abstract::Besides regulating water and electrolyte homeostasis, the mineralocorticoid receptor (MR) elicits pathophysiological effects in the renocardiovascular system. Although the MR's closest relative, the glucocorticoid receptor (GR), acts as a transcription factor at the same hormone-response-element (HRE), activated gluco...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2009.10.006
更新日期:2010-08-01 00:00:00
abstract::A facile strategy for the annulation of 2,6-dicyanoaniline moiety to steroidal A/B-ring is described from base catalyzed and microwave-promoted reaction of steroidal 3-keto-2-hydroxymethylenes with malononitrile in high yields. The generality of the reaction has been extended to non-steroidal cyclic and aliphatic keto...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.02.009
更新日期:2010-06-01 00:00:00
abstract::Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated. A simple method that does not involve extraction but only the 1:100 d...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.01.016
更新日期:2010-04-01 00:00:00
abstract::Circadian rhythms in physiology and behavior are known to be influenced by the estrous cycle in female rodents. The clock genes responsible for the generation of circadian oscillations are widely expressed both within the central nervous system and peripheral tissues, including those that comprise the reproductive sys...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.01.007
更新日期:2010-03-01 00:00:00
abstract::Oleoyl-estrone (OE) induces a marked loss of body fat in rats by maintaining energy expenditure, body protein and blood glucose despite decreasing food intake. OE increases glucocorticoids, but they arrest OE lipid-mobilization. We studied here whether OE induces a direct effect on adrenal glands function as part of t...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2009.09.009
更新日期:2010-01-01 00:00:00
abstract::Structural transformation of the steroidal lactone, oxandrolone (1), by suspended-cell cultures of the plant pathogen fungus Rhizopus stolonifer, resulted in the production of three new metabolites. These metabolites were identified as 11alpha-hydroxyoxandrolone (2), 6alpha-hydroxyoxandrolone (3) and 9alpha-hydroxyoxa...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2009.08.003
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Calcitriol, an active vitamin D metabolite, has a limited application in bone repair because of its undesirable hypercalcaemic action. However it has emerged that lithocholic acid (LCA) is a non-calcaemic vitamin D receptor ligand but whether this steroid can support osteoblast maturation has not be...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2009.07.005
更新日期:2009-11-01 00:00:00
abstract::(25S)-3-Oxocholesta-1,4-dien-26-oic acid (1) and a new (25S)-18-acetoxy-3-oxocholesta-1,4-dien-26-oic acid (2) were isolated from a soft coral Minabea sp. (cf. aldersladei) collected in North Sulawesi, Indonesia, together with two known cholic-acid-type compounds, 3-oxochol-1,4-dien-24-oic acid (3) and 3-oxochol-4-en-...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2009.04.002
更新日期:2009-09-01 00:00:00
abstract::The preparation of ring-A fused pyrimidines at the steroidal 2,3-position is herein described. The novel steroidal pyrimidines were prepared from the solid phase three-component reaction of 2-hydroxymethylene-3-keto steroids, arylaldehydes and ammonium acetate under microwave irradiation. ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2009.03.006
更新日期:2009-09-01 00:00:00
abstract::The reaction of 23-oxotigogenin acetate with TMSOTf in THF afforded the corresponding bisnorcholanic lactone in 60% yield. The analogous reactions carried out in dichloromethane or benzene gave the rearranged products--the isomeric spirostanic ketone (10-15%) and bisfuran (40-42%). Similar products were also obtained ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2009.02.010
更新日期:2009-08-01 00:00:00
abstract::Until recently, the idea that estradiol could affect cellular processes independent of nuclear estrogen receptors was often dismissed as artifact. This in spite of a large number of carefully controlled studies performed both within and outside the nervous system demonstrating estrogens regulate various intracellular ...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2008.11.013
更新日期:2009-07-01 00:00:00
abstract::Testosterone is required for the maturation of male germ cells, the production of sperm and thus male fertility. However, the mechanisms by which testosterone regulates spermatogenic processes have not been well defined. In this review, classical and non-classical pathways of testosterone signaling in the Sertoli cell...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2008.11.017
更新日期:2009-07-01 00:00:00
abstract::Effective syntheses of endo- and exocyclic alpha,beta-unsaturated ketones as CC dipolarophiles were carried out in the 13alpha-estrone series. The 1,3-dipolar cycloadditions of 15,16alpha,beta-unsaturated ketones of 13alpha-estrone 3-methyl and 3-benzyl ether with nitrilimines stereoselectively furnished two regioisom...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2009.02.001
更新日期:2009-06-01 00:00:00
abstract::The 3alpha,5alpha- and 3alpha,5beta-reduced derivatives of progesterone, deoxycorticosterone, dehydroepiandrosterone and testosterone enhance GABAergic neurotransmission and produce inhibitory neurobehavioral and anti-inflammatory effects. Despite substantial information on the progesterone derivative (3alpha,5alpha)-...
journal_title:Steroids
pub_type: 临床试验,杂志文章
doi:10.1016/j.steroids.2008.12.015
更新日期:2009-04-01 00:00:00
abstract::In this paper we report the synthesis of four fluorinated analogues of brassinosteroids in which fluorine was introduced stereoselectively at C-2. The bioactivity of these new compounds was evaluated using the rice lamina inclination test. The results show that two of these analogues elicit high bioactivity, suggestin...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.12.006
更新日期:2009-04-01 00:00:00
abstract::An efficient method to prepare 5, 9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione in one pot was reported. Treatment of 9-bromide-11-hydroxypregna-1, 4, 16-trien-3, 20-dione with Raney Ni in absolute ethanol afforded 5, 9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione by two annulation reactions in reasonable yield. The abso...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.10.018
更新日期:2009-02-01 00:00:00
abstract::Thyroid hormone receptors (TRs) are nuclear receptors that are activated by thyroid hormone ligands and co-regulator proteins. Two receptor subtypes, TRalpha and TRbeta, have been suggested to play a role in numerous physiological functions. However, specificity of receptor subtype function and co-regulator interactio...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.11.014
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Chronic administration of exogenous glucocorticoids is often required in experimental research. We compared the efficacy and reliability of three different methods of continuous glucocorticoid administration in mice. MATERIALS AND METHODS:Male CD1 Swiss White mice aged 7-9 weeks received corticosterone (CS)...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.11.009
更新日期:2009-02-01 00:00:00
abstract::Eleven new 14,15-seco-pregnane-type steroidal glycosides, cynanosides P1-P5, Q1-Q3, R1-R3, and a novel 12,13-seco-14,18-nor-pregnane-type steroidal glycoside, cynanoside S, were isolated from the roots of Cynanchum atratum, together with four known compounds, atratoside C, sublanceoside E3, chekiangensoside C and cyna...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.10.007
更新日期:2009-02-01 00:00:00
abstract::Enol aldehydes are one type of key degradation and metabolic intermediates from a group of corticosteroids containing the 1,3-dihydroxyacetone side chain on their D-rings, such as betamethasone, dexamethasone, beclomethasone, and related compounds. The formation of enol aldehydes from these corticosteroids is via acid...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.09.009
更新日期:2009-01-01 00:00:00
abstract::Mouse models of cystic fibrosis (CF) display increased sulfotransferase 1E1 (SULT1E1) activity in hepatocytes of cystic fibrosis transmembrane receptor (CFTR)-deficient animals. SULT1E1 is responsible for the sulfation and inactivation of beta-estradiol (E2) at physiological concentrations. IGF-1 message levels in CFT...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.09.002
更新日期:2009-01-01 00:00:00
abstract::1,25-Dihydroxyvitamin D(3) (1,25D) regulates gene transcription through a nuclear vitamin D receptor (VDR) which acts as a ligand-regulated transcription factor. Some structural vitamin D analogs (VDAs) are selective in their biological actions, because they retain cell-differentiating potential, while their calcemic ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.06.010
更新日期:2008-12-22 00:00:00
abstract::Chronic kidney disease results in a reduction in 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) synthesis and an accumulation of phosphorus in the blood, leading to secondary hyperparathyroidism and renal osteodystrophy. Vitamin D analogs that retain the ability to suppress PTH but that are less calcemic and phosphatemic than...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.06.003
更新日期:2008-11-01 00:00:00
abstract::Data are presented on the urinary corticosteroid metabolic profile of the mouse strain 129/svJ. Through the use of GC/MS we have characterized, or tentatively identified corticosterone (Kendall's compound B) metabolites of both the 11beta-hydroxy and 11-carbonyl (compound A) series in urine. Full mass spectra of the m...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.04.004
更新日期:2008-10-01 00:00:00
abstract::The aim of the present work was to analyze the effect of dehydroepiandrosterone (DHEA) on several metabolic risk factors, including cardiovascular health and insulin resistance, in aged rats submitted to a high-fat diet. For that, weaned rats were fed on a high-fat diet until 20 months of age. In the last 13 weeks of ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.04.011
更新日期:2008-10-01 00:00:00
abstract::The non-genomic action of steroid hormones regulates a wide variety of cellular responses including regulation of ion transport, cell proliferation, migration, death and differentiation. In order to achieve such plethora of effects steroid hormones utilize nearly all known signal transduction pathways. One of the key ...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2008.01.001
更新日期:2008-10-01 00:00:00
abstract::17beta-estradiol exerts an antiapoptotic action in skeletal muscle cells through extranuclear ERalpha and beta. This protective action, mainly involves a non-genomic mechanism of ERK1/2 and PI3K/Akt activation and BAD phosphorylation. ERbeta plays a major role in the inhibition of apoptosis by 17beta-estradiol at the ...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2007.12.027
更新日期:2008-10-01 00:00:00